Nucleotide sequence of rat c-jun protooncogene.

We isolated a clone containing rat c-jun gene from a rat liver and is highly conserved when compared with that of human cgenomic DNA-X charon 4A library by plaque hybridization with jun gene (4). Nucleotide numbers are given with the initiation P-labeled human c-jun cDNA (1) and determined the site of transcription as +1 . nucleotide sequence. The rat gene encodes a protein whose deduced amino acid sequence shares 96% and 99% identity with those of human (1) and mouse c-jun (2,3), respectively. The REFERENCES 3'-untranslated region contains three consensus signal sequences for Poly(A) addition (shown by underlines). The 5'-promoter >• gSifp^HsJ?^ ^?lS-537 region contains putative API (TGACATCA),CTF (GCCAAT) 3 Lamph,w.w. et al. (1988) Nature 334, 629-631. and SP1 (CCCGCCCC) binding sites (indicated as open boxes), 4. Hattori.K. et al. (1988) Proc.Natl.Acad.Sd.USA 85, 9148-9152.